Derivation of a No-significant-risk-level (NSRL) for dermal exposures to diethanolamine

AbstractDiethanolamine (DEA) has been found to produce liver and kidney tumors in mice following lifetime dermal exposures. Data regarding the mode of action by which DEA produces these tumors were used to support a dose-response assessment that resulted in a no-significant-risk-level (NSRL) for dermal exposures to DEA. DEA and its metabolites are structural analogs to endogenous agents important to choline homeostasis. Sufficient information is available to support an epigenetic MOA involving the perturbation of choline homeostasis and hepatic methylation reactions in the formation of mouse liver tumors. This MOA may also apply to mouse kidney tumors, but direct measurements for key events in kidney are lacking. For both tumor types, dose-response data were pooled across four cancer bioassays conducted for DEA and DEA-containing condensates in order to provide a more robust characterization of the dose-response relationships. Doses were expressed in terms of dermally absorbed dose so that the dose-dependency and species differences in the dermal absorption of DEA were addressed. The resulting NSRL value of 3400 ug/day for dermal exposures to DEA is considered to be protective of human health for both tumor endpoints

Effects of intratidal and tidal range variability on circulation and salinity structure in the Cape Fear River Estuary, North Carolina

Tidal influences on circulation and the salinity structure are investigated in the largely unstudied Cape Fear River Estuary (CFRE), North Carolina, a partially mixed estuary along the southeast coast of the United States. During two different tidal conditions (high versus low tidal range) and when river flow was low, salinity and velocity data were collected over a semidiurnal tidal cycle in a 2.8 km long transect along the estuary axis. Water level data were recorded nearby. Mechanisms that influence salt transport characteristics are diagnosed from an analysis of the field data. Specifically, we investigated the relationship between tidal range and salinity through comparison of along-channel circulation characteristics, computed salt fluxes, and coefficients of vertical eddy diffusivity (Kz) based on a parameterization and on salt budget analysis. Findings indicate up-estuary tidally driven salt fluxes resulting from oscillatory salt transport are dominant near the pycnocline, while mean advective transport dominates near the bottom during both tidal range periods. Earlier research related to salt transport in estuaries with significant gravitational circulation suggests that up-estuary salt transport increases during low tidal ranges as a result of increased gravitational circulation. In the CFRE, in contrast, net (tidally averaged) near-bottom along-channel velocities are greater during higher tidal range conditions than during lower tidal range conditions. Findings indicate stronger tidal forcing and associated mixing contribute to greater near-bottom salinity gradients and, consequently, increased baroclinic circulation. Lower near-bottom salinities during the higher tidal range period are a result of a combination of increased vertical turbulent salt fluxes near the pycnocline and increased bottom-generated mixing

F-term strings in the Bogomol'nyi limit are also BPS states

We derive the Bogomol'nyi equations for supersymmetric Abelian F-term cosmic strings in four-dimensional flat space and show that, contrary to recent statements in the literature, they are BPS states in the Bogomol'nyi limit, but the partial breaking of supersymmetry is from N=2. The second supersymmetry is not obvious in the N=1 formalism, so we give it explicitly in components and in terms of a different set of N=1 chiral superfields. We also discuss the appearance of a second supersymmetry in D-term models, and the relation to N=2 F-term models. The analysis sheds light on an apparent paradox raised by the recent observation that D-term strings remain BPS when coupled to N=1 supergravity, whereas F-term strings break the supersymmetry completely, even in the Bogomol'nyi limit. Finally, we comment on their semilocal extensions and their relevance to cosmology.Comment: 11 pages; References added, minor corrections, matches published versio

Guiding the Way to Gamma-Ray Sources: X-ray Studies of Supernova Remnants

Supernova remnants have long been suggested as a class of potential counterparts to unidentified gamma-ray sources. The mechanisms by which such gamma-rays can arise may include emission from a pulsar associated with a remnant, or a variety of processes associated with energetic particles accelerated by the SNR shock. Imaging and spectral observations in the X-ray band can be used to identify properties of the remnants that lead to gamma-ray emission, including the presence of pulsar-driven nebulae, nonthermal X-ray emission from the SNR shells, and the interaction of SNRs with dense surrounding material.Comment: 16 pages, 11 figures, To appear in the proceedings of the workshop: "The Nature of the Unidentified Galactic Gamma-Ray Sources" held at INAOE, Mexico, October 2000, (A.Carraminana, O. Reiner and D. Thompson, eds.

Pion double charge exchange on 4He

The doubly differential cross sections for the $^4$He$(\pi^+,\pi^-) 4p$ reaction were calculated using both a two-nucleon sequential single charge exchange model and an intranuclear cascade code. Final state interactions between the two final protons which were the initial neutrons were included in both methods. At incident pion energies of 240 and 270 MeV the low-energy peak observed experimentally in the energy spectrum of the final pions can be understood only if the contribution of pion production is included. The calculated cross sections are compared with data.Comment: 25 pages, 9 figure

Heavy ion beam measurement of the hydration of cementitious materials

The setting and development of strength of Portland cement concrete depends upon the reaction of water with various phases in the Portland cement. Nuclear resonance reaction analysis (NRRA) involving the 1H(15N,α,γ)12C reaction has been applied to measure the hydrogen depth profile in the few 100 nm thick surface layer that controls the early stage of the reaction. Specific topics that have been investigated include the reactivity of individual cementitious phases and the effects of accelerators and retarders

Heterotic compactifications on SU(2)-structure backgrounds

In this paper we study the reduction of heterotic string theory on SU(2)-structure backgrounds. We compute the bosonic low-energy gauged N=2 supergravity specified by the Killing vectors corresponding to the gauged isometries. We check that the obtained Lagrangian is consistent with the one of N=2 local supersymmetry. We also determine the Killing prepotentials.Comment: reference added, corrected typos and some factor

Segurança Na Mudança Direta De Natalizumabe Para Fingolimode Em Um Grupo De Pacientes Com Esclerose Múltipla E Positivos Para Jcv

To assess safety of the switch between natalizumab and fingolimod without a washout period. Methods: Prospective data on 25 JCV positive patients who underwent this medication switch were collected and analyzed. Results: After a median period of nine months from the medication switch, there were no safety issues to report. The patients had good disease control and no adverse events were reported. Conclusion: Washout may not be necessary in daily practice when switching from natalizumab to fingolimod. Expertise on multiple sclerosis management, however, is essential for drug switching. © 2016, Associacao Arquivos de Neuro-Psiquiatria. All Rights Reserved.74865065

Rewiring neuronal microcircuits of the brain via spine head protrusions--a role for synaptopodin and intracellular calcium stores.

Neurological diseases associated with neuronal death are also accompanied by axonal denervation of connected brain regions. In these areas, denervation leads to a decrease in afferent drive, which may in turn trigger active central nervous system (CNS) circuitry rearrangement. This rewiring process is important therapeutically, since it can partially recover functions and can be further enhanced using modern rehabilitation strategies. Nevertheless, the cellular mechanisms of brain rewiring are not fully understood. We recently reported a mechanism by which neurons remodel their local connectivity under conditions of network-perturbance: hippocampal pyramidal cells can extend spine head protrusions (SHPs), which reach out toward neighboring terminals and form new synapses. Since this form of activity-dependent rewiring is observed only on some spines, we investigated the required conditions. We speculated, that the actin-associated protein synaptopodin, which is involved in several synaptic plasticity mechanisms, could play a role in the formation and/or stabilization of SHPs. Using hippocampal slice cultures, we found that ~70 % of spines with protrusions in CA1 pyramidal neurons contained synaptopodin. Analysis of synaptopodin-deficient neurons revealed that synaptopodin is required for the stability but not the formation of SHPs. The effects of synaptopodin could be linked to its role in Ca(2+) homeostasis, since spines with protrusions often contained ryanodine receptors and synaptopodin. Furthermore, disrupting Ca(2+) signaling shortened protrusion lifetime. By transgenically reintroducing synaptopodin on a synaptopodin-deficient background, SHP stability could be rescued. Overall, we show that synaptopodin increases the stability of SHPs, and could potentially modulate the rewiring of microcircuitries by making synaptic reorganization more efficient